SIMBRINZA EYE DROP is a combination medication containing brinzolamide and brimonidine. It is used to lower high eye pressure in patients with open-angle glaucoma or ocular hypertension. Brinzolamide works by decreasing the production of fluid in the eye, while brimonidine works by increasing the drainage of fluid from the eye. This combination helps to reduce the pressure inside the eye, which can help prevent vision loss. SIMBRINZA EYE DROP is typically used twice a day, with one drop in the affected eye(s). It is important to follow the dosing instructions provided by your healthcare provider and to not stop using the medication without consulting them first.