Simbrinza Eye Drop is a combination medication that contains brinzolamide and brimonidine. Brinzolamide is a carbonic anhydrase inhibitor that reduces the production of fluid in the eye, while brimonidine is an alpha agonist that decreases the amount of fluid in the eye and increases the drainage of fluid. This combination helps to reduce high eye pressure, which can help prevent vision loss in patients with open-angle glaucoma or ocular hypertension. Simbrinza Eye Drop is typically used as a long-term treatment and is administered as eye drops.