ISTAMET 50/500 TABS is a combination medication containing two active ingredients – sitagliptin and metformin. Sitagliptin works by increasing the levels of incretin hormones in the body, which helps to control blood sugar levels. Metformin works by decreasing glucose production in the liver and improving insulin sensitivity. This medication is used to treat type 2 diabetes and helps to lower blood sugar levels. It is usually taken orally with meals. However, it is important to follow the dosage and administration instructions provided by your healthcare provider.